http://bugs.winehq.org/show_bug.cgi?id=12695
--- Comment #1 from Lei Zhang thestig@google.com 2008-04-22 00:31:19 --- It works if you return in libs/wine/config.c around line 212 when errno == ENOENT. Maybe Alexandre did it on purpose to prevent wineprefixcreate from running in case you made a typo in $WINEPREFIX ?