http://bugs.winehq.org/show_bug.cgi?id=24601
--- Comment #14 from 3vi1 winehq.org@eternaldusk.com 2011-12-07 14:24:57 CST --- Confirming that this is still present in 1.3.34:
Starting validation of Left 4 Dead 2 Validation failure: w:\games\steam\steamapps\common\left 4 dead 2\left4dead2\bin\client.dll Validation complete: 51984 Total Files, 1 Failed Validation
This is now running from an Ext4 partition (as opposed to BtrFS when I first reported it). The system is a completely reinstalled - Ubuntu 12.04-alpha1 w/3.2r4(mainline) kernel.
The game appears to work fine for me otherwise.