https://bugs.winehq.org/show_bug.cgi?id=48134
--- Comment #23 from Michael Stefaniuc mstefani@winehq.org --- I have compared the logs between the working 4.10 and the broken 4.11 and it starts to diverge with this: -0009:warn:ole:enter_apartment Attempt to change threading model of this apartment from apartment threaded to multi-threaded <puk> -0009:trace:ole:CoCreateInstance (rclsid={e436ebb3-524f-11ce-9f53-0020af0ba770}, pUnkOuter=00000000, dwClsContext=00000001, riid={56a868a9-0ad4-11ce-b03a-0020af0ba770}, ppv=001AA094)
Doing a grep for that GUID:
luna:/j/wine/bottles$ grep -ri e436ebb3-524f-11ce-9f53-0020af0ba770 hydorah-wine-4.10/ Binary file hydorah-wine-4.10/drive_c/windows/system32/quartz.dll matches hydorah-wine-4.10/system.reg:[Software\Classes\CLSID\{E436EBB3-524F-11CE-9F53-0020AF0BA770}] 1578685952 hydorah-wine-4.10/system.reg:[Software\Classes\CLSID\{E436EBB3-524F-11CE-9F53-0020AF0BA770}\InprocServer32] 1578685952 luna:/j/wine/bottles$ grep -r e436ebb3-524f-11ce-9f53-0020af0ba770 hydorah-wine-4.11/ luna:/j/wine/bottles$
That GUID disappears from the registry for whatever reason. That explains why an once broken WINEPREFIX stays broken.