https://bugs.winehq.org/show_bug.cgi?id=47125
--- Comment #6 from jeffersoncarpenter2@gmail.com --- The mmap2 calls that the preloader uses to reserve the regions are bounced in valgrind because they would clobber parts of its process image. Running sed -i 's/0x58000000/0x68000000/' configure.ac before compiling valgrind clears some of the warnings, but doing that is arbitrary. Valgrind also uses mmap(NULL, ...) to allocate heap memory, which too collides with Wine's attempted preloads.
Sorry for the double post -- Links is touchy.