https://bugs.winehq.org/show_bug.cgi?id=48533
--- Comment #10 from ryan@rnrcarpet.com ---
While you can build a 64-bit only wine, note that many 64-bit applications mix > in 32-bit components and that will fail with such a setup.
Currently wondering if that answers my previous question that a 64 bit prefix may make use of 32 bit wine code. It sounds like this might what is meant.
make distclean rm -rf wine64-build rm -rf wine32-build
git add . git reset --hard HEAD git pull
Same problem. It starts but then fails as above.
WINEPREFIX=/path/to/prefix ./wine theprogram
Yes, did that mostly for a while to not conflict with distro installed wine.