http://bugs.winehq.org/show_bug.cgi?id=12846
--- Comment #6 from Dan Jones djones9960@gmail.com 2008-06-05 03:39:21 --- It suspect this to be hardware-specific. I've installed the game on my older single-core AMD64 machine and it doesn't work at all, either with Wine or Winedbg.
I may try later with an AthlonXP machine I have, and do a backtrace on all three to try and see what on Earth is going on. Maybe the errorcodes given by CD/DVD drives are non-standard (I believe non-readable parts of the disk are what safedisc relies on)