http://bugs.winehq.org/show_bug.cgi?id=11761
--- Comment #5 from Austin English austinenglish@gmail.com 2008-03-03 12:15:41 --- (In reply to comment #3)
I did not say wine freezes machine, but that running winecfg freezes machine. Fault may be elsewhere but is triggered by running winecfg and by nothing else in my experience. Some interaction no doubt.
What drivers do you mean ? Check them how?
Video drivers most likely. Try another version/updating them/vesa/generic drivers and see if the same occurs. ATI is known for buggy drivers.