https://bugs.winehq.org/show_bug.cgi?id=50557
--- Comment #9 from Zebediah Figura z.figura12@gmail.com --- Apparently most of the source of Mod Organizer 2 is available on GitHub. I couldn't find any mention of reparse points or GetVolumePathName() in the code, though. It could be that my guess was wrong, though it could also be that the game itself doesn't like being run from a mounted folder.
What exactly fails? "USVFS no longer working" is not very specific (not to mention that the problem may very well have nothing to do with USVFS...)