http://bugs.winehq.org/show_bug.cgi?id=10406
--- Comment #15 from Forest Hale lordhavoc@ghdigital.com 2009-05-17 05:24:57 --- Be careful with any NoDVD patch, because TQ itself was famous for crashing randomly every 5-15 minutes if the protection was disabled in any way, it was never fully removed by any of the patches that were released; indeed, many of the user reviews on the web are from people using a NoDVD patch and reporting it as being crashy, without realizing it was entirely based of the NoDVD patch.
However Titan Quest v1.30 supposedly removed the protection.
The Immortal Throne expansion never had the protection in the first place and is the only one I test, so it may be far more stable than Titan Quest itself.