I also encounter problems when using ttyUSB0/1 in wine. My GPS-USB works fine under linux, but as soon as i access the connected device to COM1=/dev/ttyUSB0 the wine-app (german navigation-software: Map&Guide v9) crashes with a "access violation at ..."
Would be very nice if gps and other usb-serials would work with wine (not only, but especially because of the lack of proper car-navigation-software for linux)
Greetings
Tobias