http://bugs.winehq.org/show_bug.cgi?id=17614
--- Comment #14 from Richard shiningarcanine@gmail.com 2010-11-26 15:15:45 CST --- I did some more testing and this is still an issue. With a fresh installation, the background video is a black screen, so I edited rise2.ini to set ForceLowCPUBackgroundVid to 1. Doing that somehow fixes the mouse issue.
I had issues with the Rise of Nations installer in WINE 1.3.7, but the release announcement for 1.3.8 just came out. I tested this in WINE 1.3.8 and the behavior is still like this.