http://bugs.winehq.org/show_bug.cgi?id=15161
--- Comment #17 from Vitaliy Margolen vitaliy@kievinfo.com 2008-09-08 09:02:59 --- (In reply to comment #16)
[glenn@polaris ~]$ wine "D:\setup.exe"
You're not running it correctly. Please read comment #2 again.
The easiest way would be to use this command instead: wine start /unix /media/dvd/setup.exe