https://bugs.winehq.org/show_bug.cgi?id=39305
--- Comment #2 from paulo i30817@gmail.com ---
Combining the previous workaround of using gdi for the mouse problem still works. Use these on the prefix you're running the game on:
wine reg add "HKCU\Software\Wine\Direct3D" /v "OffscreenRenderingMode" /t REG_SZ /d "backbuffer" wine reg add "HKCU\Software\Wine\Direct3D" /v "DirectDrawRenderer" /t REG_SZ /d "gdi"
and you'll have native fullscreen with a image without the mouse problem... i think. Didn't test extensively.