https://bugs.winehq.org/show_bug.cgi?id=43009
--- Comment #22 from Dmitry Timoshkov dmitry@baikal.ru --- In short: the unresponsive window in question is a layered window with an assigned color key. I guess that the window surface bitmap is used as a layer mask, and is supposed to be "transparent" both visually and for mouse clicks. winex11.drv calculates the mask shape and instructs the WM about it, so WM sends the button click event to an underlying window. But user32 side is not aware about that masked shape, and currently there is no way to check for it from WINPOS_WindowFromPoint.