https://bugs.winehq.org/show_bug.cgi?id=44032
--- Comment #8 from Steve Soule sts33nvyb@gmail.com --- Adam, have you tried tweaking the various settings related to windowed mode and desktop emulation? Several people on the Diablo 3 appdb page reported that this helped for them.
My computer: OpenSuse 42.3 x86_64, KDE, i5-4460, 8 GB RAM, Nvidia GTX 460, 1920x1200, kernel 4.4.92-31, nvidia driver 384.98, mouse Logitech G402.