http://bugs.winehq.org/show_bug.cgi?id=34480
--- Comment #16 from Riccardo c10ud.dev@gmail.com --- @all
Stefan told me he would look into a proper fix for this issue after the d3d command stream patches, it will probably take a while (hopefully it will be soon :)) meanwhile I suggest you all patch LoL with A-Metaphysical-Drama's tool:
https://github.com/A-Metaphysical-Drama/LoL-Linux-Tools/
League of Legends no longer detects this patch as corrupt data so once you run it once you're done.
greets