http://bugs.winehq.org/show_bug.cgi?id=16822
--- Comment #8 from Kol kol@MV8660.spb.edu 2009-02-05 11:15:41 --- (From update of attachment 19267) Mouse works correctly in game and in menu after applying the patch to Wine 1.1.14 and using the native dinput8.dll. This patch is a variant of the patch from "http://bugs.winehq.org/attachment.cgi?id=11737" (it virtualizes mouse pointer, see bug #6971) and changes only "winex11.drv.so". This is, obviously, a temporal workaround because the patch breaks mouse movements in some other games (TES3:Morrowind, for example). But there is a method to avoid this breaking and use the improved version for Mass Effect exclusively. One have to install the original Wine, then recompile the patched "winex11.drv.so", rename it to "winex11.drv" and place it into the "Bioware/Mass Effect/Binaries" directory.