http://bugs.winehq.org/show_bug.cgi?id=28726
--- Comment #2 from howy@ovi.com 2011-10-15 12:10:42 CDT --- (In reply to comment #1)
[POL_Wine_SetVersionEnv] Message: Setting wine version path: 1.3.26, x86 [POL_Wine_SetVersionEnv] Message: "/home/havard/.PlayOnLinux//wine/linux-x86/1.3.26" exists [POL_Wine] Message: Running wine-1.3.26 /mnt/Startup.exe err:winediag:wined3d_dll_init The GLSL shader backend has been disabled. You get to keep all the pieces if it breaks.
PlayOnLinux isn't supported here. Additionally, test in latest version (1.3.30), and don't disable glsl, as that message tells you.
I don't think PlayOnLinux is relevant. It's only a prefix manager, and does not have anything to do with how Wine works by itself.