https://bugs.winehq.org/show_bug.cgi?id=48965
--- Comment #5 from Zebediah Figura z.figura12@gmail.com --- Sorry for the long delay in getting to this.
I just tried to launch Rift, assign alt-6 to a skill, and press it, and the game did respond, both when assigning the key binding and when using it. It works also in both windowed and fullscreen mode.
Can you please check with current Wine (i.e. 6.0-rc1)? This bug may have been fixed.
If you can still reproduce it, can you please attach a new log with WINEDEBUG=+dinput,+rawinput,+win,+keyboard,+key,+event,+server?