http://bugs.winehq.org/show_bug.cgi?id=31071
--- Comment #40 from Anton Vorobyov phoenix@mail.ru 2012-07-21 04:33:54 CDT --- Well, i think we better remove all references to Luna from this bug then and create a new one for her nasty aura, as originally everything but luna was described.
Orianna, wine git is current public development version of wine, updated on daily basis in git repository. Wineskin probably has something else on top of wine so your case a bit more complex.
Yuri Shishenko, it could be some session-specific setting you changed before running dota. E.g. after each reboot i had to launch nvidia x server settings to make sure vsync is disabled (this way i got 125 fps in quake live opposed to 60, because previous versions of nvidia driver always turned vsync on by default due to some reason). Could also be some environment variables...