https://bugs.winehq.org/show_bug.cgi?id=49836
--- Comment #1 from Esme Povirk madewokherd@gmail.com --- 00f4:fixme:mscoree:CLRCreateInstance not implemented for class {90f1a06e-7712-4762-86b5-7a5eba6bdb02}
It's doing CLRCreateInstance(&CLSID_CLRRuntimeHost, &IID_ICLRRuntimeHost, &iface), but testing on Windows shows that this doesn't work: https://testbot.winehq.org/JobDetails.pl?Key=78923
So, the failure must be elsewhere.
Also, you should probably install native .NET for this.