http://bugs.winehq.org/show_bug.cgi?id=12962
--- Comment #2 from Vitaliy Margolen vitaliy@kievinfo.com 2008-05-11 13:45:52 --- Do you have any mouse emulators running? Or some other input altering programs? If it works with one config and not with another the X-server is still the same. And this is where Wine gets it's mouse & keyboard events from.
Also do you have that problem without compiz all together?