http://bugs.winehq.org/show_bug.cgi?id=12771
--- Comment #33 from - farfrael@googlemail.com 2010-11-19 15:23:02 CST --- using regedit to create the following settings solved the "transparent characters" issue
[HKEY_CURRENT_USER\Software\Wine\Direct3D] "DirectDrawRender"="opengl" "OffscreenRenderingMode"="fbo" "PixelShaderMode"="enabled" "RenderTargetLockMode"="textex" "UseGLSL"="enabled" "VideoMemorySize"="xxx" <=== replace xxx by the memory on your GFX card (i.e. 512 or 1024 etc)
health bars still not visible but at least game is playable