http://bugs.winehq.org/show_bug.cgi?id=24861
--- Comment #9 from Joe Polak joe.polak.3@gmail.com 2011-06-13 10:12:16 CDT --- (In reply to comment #8)
After a bit of testing I've found that the crash usually occurs when attempting to overwrite a previous save game. Even saving over a manually saved game will cause the game to crash and corrupt the file.
So far, sticking with manual saves( or quick saves possibly )and disabling autosave has resulted in a stable experience.
Based on this description, and many more hours of my own testing, I think I'm experiencing a different bug which somehow involves the game's graphics. It'll be a while before I can test it again using latest wine.