http://bugs.winehq.org/show_bug.cgi?id=27472
Summary: Duke Nukem Forever hangs in many locations. Product: Wine Version: 1.3.22 Platform: x86 OS/Version: Linux Status: UNCONFIRMED Severity: normal Priority: P2 Component: -unknown AssignedTo: wine-bugs@winehq.org ReportedBy: mblackwell1024@gmail.com
While getting the game to start can be difficult (every game start a crash dialog will display and the game may or may not launch when it is closed) it does run. However in various scenes the game will hang.
In the intro map looking around will cause the game to hang. You can bypass this crash by looking down and strafing out to the hallway. The game will then play normally until you get a level involving a television station. The game will then hang if you try and explore the employee lounge. Again, you can avoid this area and continue to play. From there I had no issues until it loaded up the level Lady Killer. After pressing Space to start the level the game again hangs.
There's no console output specific to this event. I'll post any log info from requested debug variables in order to help someone track down this issue.