https://bugs.winehq.org/show_bug.cgi?id=49786
--- Comment #6 from Murray Colpman muzerakascooby@gmail.com --- Before my change, horizontally scrolling actually generated Mouse Button X1/X2 events, which are usually used for browser back/forward buttons, rather than horizontal scrolling. After my change horizontally scrolling now generates proper horizontal scroll events, just like the input drivers for other systems (eg Mac). When I tested an old version of Firefox which I could get running in wine, the horizontal scrolling worked after my change and did not work before it.
Did you perhaps manually change the controls mapping ingame before the change, which now since the change has led to them not working? Have you tried simply remapping using the game's own settings? Or does it not let you do that?