https://bugs.winehq.org/show_bug.cgi?id=38313
--- Comment #4 from Andrew Eikum aeikum@codeweavers.com --- Yuki, I'm not sure what asoundrc settings you used. Wine will try the device named "default" and any direct hardware devices that ALSA enumerates. If you changed "default", I would expect Wine to pick up on that. It won't pick up on any custom devices automatically. If you created a new device and want Wine to use it, you can use the ALSAOutputDevices registry setting:
http://wiki.winehq.org/UsefulRegistryKeys
Can you reconfigure your settings to how you'd expect them to be? For example, if you have 4.1 physical speakers, set that correctly in winecfg; reset to your usual "default" ALSA device; put Skyrim's settings how you'd like them to be. Let me know what these settings are.
Then, play Skyrim just long enough to demonstrate the issue, and attach a log with the channels from http://wiki.winehq.org/Sound. The log file will grow large very quickly, so you'll want to compress it before you upload.