http://bugs.winehq.org/show_bug.cgi?id=33093
--- Comment #1 from Vincent Povirk madewokherd@gmail.com 2013-03-02 13:43:14 CST --- Does 'wine notepad' work?
If you can get a backtrace with debugging symbols (either install your distro's "debug" package for Wine, probably called something like wine-dbg, or build Wine from source), that would make it easier to tell what's going on.
For now, my guess is that fallout 3 includes something that sets a global windows hook, and that hook is not working correctly. Common practice is to use a separate wineprefix for each application, so that they can't break each other (see http://wiki.winehq.org/FAQ#wineprefix).
(It seems rather suspicious to me that fallout 3 would install something like this. Now, I'm not saying you're a pirate, nor do I necessarily have a problem with piracy, but if you do have a crack or pirated copy then it could explain why this is happening. If that's the case, well, as a rule we do not work on fixing such things. But maybe there is some other reason, like really egregious DRM.)