https://bugs.winehq.org/show_bug.cgi?id=37784
--- Comment #1 from Vincent Povirk madewokherd@gmail.com --- Wine Mono installs in a new prefix regardless of the wine command used to create it. The source of confusion in that bug is that 'wine uninstaller' invokes the 32-bit uninstaller.exe, which can't see Wine Mono because it installed as a 64-bit package. This does not impact Wine's ability to run 32-bit .NET software.
I think we should make uninstaller.exe reinvoke itself as 64-bit if it's run in a wow64 mode, similar to what winecfg does.