http://bugs.winehq.org/show_bug.cgi?id=27158
--- Comment #7 from GyB gyebro69@gmail.com 2011-05-15 04:57:24 CDT --- (In reply to comment #6)
Does the 'lagging' feel like a sudden massive loss in FPS? If so, I've seen this issue as far back as 1.3.10 or so. It appears totally at random and I think it's unrelated to this.
No, it is due to http://source.winehq.org/git/wine.git/commit/a59c7cc8596b658d3c0854a737528cf...
This is the commit which introduced the strange mouse jumping issue. It happens occasionally but frequently enough to annoy you while playing. The other two commits in comment #5 made the problem more serious: the jittery mouse movement became persistent.