https://bugs.winehq.org/show_bug.cgi?id=39567
--- Comment #1 from Rosanne DiMesio dimesio@earthlink.net --- You have to change the Windows version for the Apply button on that tab to become active, and you have to change some setting for the application (Windows version or some override) for it to be saved when you click OK. If you haven't changed any settings, there's nothing to apply or save.