http://bugs.winehq.org/show_bug.cgi?id=27298
--- Comment #21 from Jonathan Strander mblackwell1024@gmail.com 2012-10-26 08:25:22 CDT --- What else is there other than +fps? And yes I know how the command works and tracked it over long periods to make sure I had accurate counts.
Also yes I do load nvidia-settings (nvidia-settings --load-config-only).
The difference is great enough that it points to some bad interaction between Application -> Wine -> Everything Else. Also I use GNOME Shell so when switching to Metacity most of the desktop is unloaded and there is an FPS increase, but it's small enough (only a couple of FPS) to not make much difference overall.