https://bugs.winehq.org/show_bug.cgi?id=46981
--- Comment #3 from Austin English austinenglish@gmail.com --- (In reply to Andy P from comment #2)
Following... I've not yet been able to get a dotnet4 (or any subsequent 4.x dotnet release) running on a win64 prefix from the Mac.
Frankly; I've never tried. I spent a bit of time adding some basic tests for this to winetricks (built helloworld.exe with mono's mcs, then added that to winetricks_dotnet_verify).
4.0 and 4.5 work, but 4.6.1/4.6.2/4.7.1/4.7.2 fail. I couldn't test 4.8, as mono's mcs doesn't support building 4.8.
To be fair, I haven't tested the binaries on Windows.