https://bugs.winehq.org/show_bug.cgi?id=47198
--- Comment #101 from Matías Zúñiga matias.nicolas.zc@gmail.com --- If the question is whether the patches here can be applied upstream, I think the answer is no, because the current solutions depend on having a customized glibc or disabling vdso32 at a kernel level. And probably nobody will try a different approach knowing that it will probably stop working with the 2021 changes
For now you can run league in wine 5.11 and 5.10 with the patches at Bug 49412 and wine 5.6 through 5.9 with the alternative patches here.