https://bugs.winehq.org/show_bug.cgi?id=48046
--- Comment #7 from dereklesho52@Gmail.com --- As Matteo mentioned, the game repeatedly acquires and unacquires the mouse while MOUSE1 is held down. When this happens wineserver usage goes up to 100% of a core, so I'd guess messages aren't being processed by the application.
I think a good next step would be to find out whether a wine bug is causing the game to exhibit this behavior, and then if not, whether Windows handles this without locking up the game.