http://bugs.winehq.org/show_bug.cgi?id=33413
--- Comment #4 from Frédéric Delanoy frederic.delanoy@gmail.com 2013-05-01 15:24:45 CDT --- (In reply to comment #3)
Are you using setarch i386 -3 wine diablo3.exe to lunch the game?
No. Never had.
When warden its active on server side playing the game without setarch in a x86_64 enviroment always brings gui corruption, low fps and gui elements stopping to response. Also Auction house stops to work.
I have no GUI corruption, just non-responsive stuff.
Lunching the game with setarch i386 -3 fix the issue, however the performance decreases a little.
Launching with "setarch i386 -3" works around the issue, yes (but that's not a real fix). Note I never had such issues before the mentioned "regression commit".