https://bugs.winehq.org/show_bug.cgi?id=50502
--- Comment #2 from Hans J hans@betafreak.com --- This is a default modus operandi in Unreal Engine 4 games that use voice chat. The free-to-play game Unfortunate Spacemen on Steam is one such example (https://store.steampowered.com/app/408900/Unfortunate_Spacemen/), with the added factor that proximity-based chat is integral to how the game works. This issue manifests in the game as no one being able to hear me speak even when I hold the push-to-talk button and mic audio works in other games.
In order to test that this is a problem with vanilla Wine (and not just Steam Proton), I installed Steam for Windows into Wine and ran the game through it as well, and got the same issue.
I suspect that the issue would also be replicated in Epic's Fortnite and Riot's Valorant, though both of those games have anti-cheat components that make running in Linux impossible as of now.