http://bugs.winehq.org/show_bug.cgi?id=31262
--- Comment #12 from Dave Thompson administrator@olympicsoftworks.org 2013-11-05 02:20:15 CST --- Haven't been able to get any play time until just now and I lost mouse control in about 5 min. Once that happens I can get it back by CTRL-ALT-ARROW to another desktop, where I have to move the mouse and click on the desktop. Then I CTRL-ALT-ARROW back to D3 and I have mouse control for 10-15 seconds.
I have not been able to figure out exactly what action drops the mouse. And it's wierd, because I can highlight different dropped items by moving the mouse around. So it's just that the visual cursor is getting disconnected from where the game thinks it should be.