http://bugs.winehq.org/show_bug.cgi?id=9788
--- Comment #5 from Bleeter Yaluser winehq-bugzilla@bleeter.id.au 2007-09-26 22:21:54 --- Kris, Yeah, there's still quite a few reports of audio issues on Win32 native, leading me to suspect it's more than likely an upstream issue - although I'm not discounting the possibility it might be a Wine issue causing your (or other) problems.
As such, I think we should keep this bug report open, although no action should be taken until such time as we see some indication from upstream that their cleanup rate is improving.
Some things to note, though, is that for a number of people reporting issues in Wine, fiddling with various audio settings in winecfg, as well as maybe lowering the number of soundchannels ingame (via the audio options menu) may help. Additionally, if your server doesn't have voice chat available for it, make sure that it's disabled in the Config.wtf settings.