https://bugs.winehq.org/show_bug.cgi?id=47198
--- Comment #117 from Matías Zúñiga matias.nicolas.zc@gmail.com --- Hi!. Since the 13.7 version, League of Legends uses a 64-bit game client, and the patches here are no longer needed, so I think this bug should be closed.
Now, the only bug that prevents the game from running is Bug 54800. There is also Bug 51687 that prevents the RiotClient from updating itself, and Bug 54793 (from LeagueClient) which has a known workaround.