https://bugs.winehq.org/show_bug.cgi?id=38345
--- Comment #3 from Josh winehq@iooioio.hadar.uberspace.de --- I just retested this with Wine 2.0 and it's hard to say whether this bug is still present because I'm testing from a new (and more powerful) machine.
Nevertheless, FPS seems to drop from about 55 to 25 or so during the battle in the building. It's not completely unplayable but I'm pretty confident I would be getting 60 FPS+ with this rig on Windows.