https://bugs.winehq.org/show_bug.cgi?id=43273
--- Comment #4 from murks@tuxfamily.org --- My thoughts exactly. That's why I've asked in several places for people to reproduce. Especially with Nvidia.
Kallestofeles tried to reproduce yesterday, with proprietary nvidia drivers. He could not use my save game due to missing DLC, so it's actually a different version of the game. This may or may not be relevant. Anyways, he had severe slowdowns when he looked in a certain direction at hanged man's tree. I guess this indicates a problem with the game or wine. He had no problems in the area of my save game. His machine did not freeze up.
This is at least an indication that it is a problem in either mesa or amdgpu. I wish someone would try to reproduce with amdgpu-pro and nvidia with my save game. the former I can try (had trouble installing amdgpu-pro). The later I can not do.
That would point to the culprit with some certainty (although it's often a combination of factors).