http://bugs.winehq.org/show_bug.cgi?id=10282
--- Comment #13 from Szabolcs Szakacsits szaka@ntfs-3g.org 2007-11-06 06:55:44 --- jestersi: I already explained what's your problem at http://bugs.winehq.org/show_bug.cgi?id=10282#c9
If you use the 'users' mount option then mount(2) will be done with the 'noexec' mount option (you can confirm this by checking out the ntfs-3g log messages under /var/log) and you will not be able to mmap programs for execution.
Solution: add the 'exec' option to the __END__ of the mount options. Like:
/dev/hda2 /mnt/ntfs2 ntfs-3g users,uid=1000,gid=1000,exec 0 0
Then Wine will work fine like in the other cases.