http://bugs.winehq.org/show_bug.cgi?id=11038
--- Comment #3 from Lei Zhang thestig@google.com 2008-01-06 03:50:10 --- (In reply to comment #1)
You sure this is with clean ~/.wine dir? Sounds more like you got yourself a virus/root-kit that wants to mess with the kernel.
Hrm, no, I wasn't using a clean .wine directory. It turns out culprit is pxhelp20.sys, bundled with Picasa. (and many other windows software that do cd burning)