https://bugs.winehq.org/show_bug.cgi?id=51582
--- Comment #7 from Esme Povirk madewokherd@gmail.com --- When I try to run s4pe here, I get this error: Unhandled Exception: System.NullReferenceException: Object reference not set to an instance of an object at S4PIDemoFE.Properties.Settings.get_FormWindowState () [0x0000c] in <0fadfef0de9940dfb852d423eeb74c0c>:0 at S4PIDemoFE.MainForm.MainForm_LoadFormSettings () [0x00010] in <0fadfef0de9940dfb852d423eeb74c0c>:0 at S4PIDemoFE.MainForm..ctor () [0x001c6] in <0fadfef0de9940dfb852d423eeb74c0c>:0 at S4PIDemoFE.MainForm..ctor (System.String[] args) [0x00000] in <0fadfef0de9940dfb852d423eeb74c0c>:0 at (wrapper remoting-invoke-with-check) S4PIDemoFE.MainForm..ctor(string[]) at S4PIDemoFE.Program.Main (System.String[] args) [0x0001a] in <0fadfef0de9940dfb852d423eeb74c0c>:0
I think you must have native mscoree.dll installed somehow at least.