https://bugs.winehq.org/show_bug.cgi?id=39023
--- Comment #47 from Naan wine@sharpner.de --- No need to be sorry. :)
To be honest I have no clue about "portingkit". But one requirement of patching wine is to install from source. I would guess that portingkit uses a binary (non-source) distribution of wine, and therefore patching would not work.
If you have enough disk space, I think you can try installing it both ways.
In generell homebrew is a great way to manage packages and software on your mac, so you should try it anyways :P