http://bugs.winehq.org/show_bug.cgi?id=14432
--- Comment #1 from Vitaliy Margolen vitaliy@kievinfo.com 2008-07-13 01:19:55 ---
szg@szg: ~.szg@szg:~$ wine /home/szg/.win.e/drive_c/Program\ Files/Design\ Explorer\ 99\ SE/Client99SE.exe
You not running it right - you have to 'cd' into program's directory first.
err:process:init_windows_dirs directory L"%SystemRoot%" could not be created, error 2
Looks like your Wine configuration is busted. Did you happened to run it as root which broke everything?
wine: Call from 0x7ee4ee60 to unimplemented function ntoskrnl.exe.KeInitializeSemaphore, aborting .. PE 450000- 452e20 Deferred ckldrv.sys
This appears to be a part of "CrypKey Software License Manager". If that's the case it won't work on Wine as-is.