http://bugs.winehq.org/show_bug.cgi?id=20593
--- Comment #1 from Justin Newman eqisow@gmail.com 2009-11-06 12:44:28 --- The issue seems to occur when the mouse reaches the edge of the screen, but as I understand it the mouse should either stay centered while moving OR should keep turning when it reaches the edge. There is a known problem with the screen edge detection of Compiz with fullscreen apps, because it places 1 pixel transparent windows on the screen borders that stay above fullscreen games.
However, I'm using KDE/Kwin, which I don't think has this behavior. I'll try to look into it further.