https://bugs.winehq.org/show_bug.cgi?id=37202
--- Comment #3 from Vincent Povirk madewokherd@gmail.com --- The issue with separate prefixes is unfortunately a limitation of Wine: CreateFile sharing semantics don't exist on Linux, and so we have to implement them in wineserver, meaning they only work within the same prefix. Multiple instances of Word in separate prefixes (including over network shares with Windows, if range locking works on the network filesystem) should work correctly, because of the change that caused this bug.
Please file a LibreOffice bug and CC me. It's debatable whether they're really doing anything wrong (though I would argue that they have to be prepared to interact with Windows programs over a network share, and what they're currently doing could break that), so enhancement seems appropriate, but I don't think we can fix it on our end.