https://bugs.winehq.org/show_bug.cgi?id=43182
--- Comment #1 from Ken Thomases ken@codeweavers.com --- By default, both Command keys send Windows Alt. The Option keys (which on some keyboards are labeled "Alt") are used to access additional characters from the keyboard layout.
There is not currently any way to change what the Command keys send. If you want to change it so the Option keys send Alt, too, you can set either or both of these registry settings:
[HKEY_CURRENT_USER\Software\Wine\Mac Driver] "LeftOptionIsAlt"="y" "RightOptionIsAlt"="y"